Future Direction
The most obvious next step for the algorithm is to utilize more variables from the TCD spectrum to increase the specificity and sensitivity of detection. In the absence of experimental data, we could not fully explore the utility of wave form analysis and the other measurements we discussed in the beginning of this section. We found no evidence of experimentally determining whether the harmonic coefficients from Fourier analysis of TCD signals give any information about vessel patency and we think this is an interesting topic for future study.
If the harmonic coefficients are unique, we could make a library of TCD flow signals and define the Thrombolysis in Brain Ischemia (TIBI) flow grading system within our algorithm and automate the detection of recanalization initiation by following the criteria identified by Alexandrov outlined in Parameters.
Furthermore, the potential of embolic signals from the magnetite particles poses an interesting scenario for TCD examinations. We would like to see further research in this field.
If the harmonic coefficients are unique, we could make a library of TCD flow signals and define the Thrombolysis in Brain Ischemia (TIBI) flow grading system within our algorithm and automate the detection of recanalization initiation by following the criteria identified by Alexandrov outlined in Parameters.
Furthermore, the potential of embolic signals from the magnetite particles poses an interesting scenario for TCD examinations. We would like to see further research in this field.